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Aroosha Raja

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The impact of ERAP1 inhibition on metabolite homeostasis of melanoma cells - Scientific Reports

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By Martha Nikopaschou, Jeannette Ossewaarde-van Norel, Anna Artati, Michael Witting, Efstratios Stratikos, Jonas Kuiper, Aroosha Raja, Joke H. de Boer
| Nature Verified
Abstract Manipulation of the activity of Endoplasmic Reticulum AminoPeptidase 1 (ERAP1) has emerged as a powerful tool for the modulation of the cellular antigenicity and concomitant adaptive immune responses, with potential applications in cancer immunotherapy and Major Histocompatibility class (MHC)-associated autoimmunity being explored. Small molecule inhibitors often target allosteric sites of ERAP1 to achieve superior selectivity.
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