Arpine Grigoryan on Muck Rack

Arpine Grigoryan

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Articles

Transcriptomic profiling identifies immunotherapy-responsive phenotypes in microsatellite-stable metastatic colorectal cancer

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By Tomas Konecny, Henry Loeffler-Wirth, Chloe Delepine, Dhan Chand, Hans Binder, Nate Zadirako, Arpine Grigoryan, Melina Tamazyan, Sveta Mnatsakanyan, Luiza Stepanyan, Sean Bourdelais, Gabriel Mednick
| Nature Verified
Abstract Conventional immune checkpoint inhibitors (ICIs) remain largely ineffective in microsatellite-stable metastatic colorectal cancer (MSS mCRC), where low tumor immunogenicity and molecular heterogeneity across metastatic sites underpin therapeutic resistance. We present a comprehensive transcriptomics analysis of metastatic and primary tumor biopsies from MSS mCRC patients treated with botensilimab (BOT; Fc-enhanced anti–CTLA-4) ± balstilimab (BAL; anti–PD-1).
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