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Arpit Sharma

As seen in: Medium, Nature, The Times of India, Wiley Online Library, PLOS, MDPI, ZDNet, ACS Publications, Science Magazine, Royal Society of Chemistry and
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Articles

An attention-guided multimodal deep learning framework by integrating CT-PET imaging and clinical data for lung cancer detection

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By Ritika Dubey Verified, Arvind Dhaka, Amita Nandal, Arpit Sharma
| Nature Verified
Abstract The proposed multi-modal deep learning system for lung cancer diagnosis and characterisation uses structural (CT), functional (PET), and clinical (EHR) data. The heterogeneous information fusion technique uses a clinical data encoder, an attention-based fusion mechanism, and a convolutional neural network backbone for image feature extraction. Multi-task learning combines tumor categorization and characterization.
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AMPK γ-Subunit Isoform Switching Governs Temozolomide Resistance and Survival in Glioblastoma

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By Shweta Dongre, Arpit Sharma, Naveen Soni
| preprints.org
You are already at the latest version Temozolomide (TMZ) resistance remains a fundamental obstacle in the treatment of Glioblastoma (GBM). While the metabolic sensor AMPK is known to influence cancer cell survival, the specific role of its regulatory γ-subunit isoforms in orchestrating chemoresistance is poorly understood. This study investigates how dynamic remodeling of the AMPK heterotrimer contributes to TMZ evasion in GBM.
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Peroxisomes orchestrate metabolic flexibility and longevity via an interorganelle cascade

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By Arpit Sharma, Aditi Prabhakar, Miriam Valera-Alberni, Jamie Kraft, Abigail E. Ellis, Ryan D. Sheldon, Meeta Mistry, Pallas Yao, Yanshan Liang, Sheng Hui, William B. Mair
| Nature Verified
Abstract Aging impairs coordinated organelle dynamics essential for lipid metabolism, causing a decline in intracellular metabolic flexibility. However, the drivers of organelle collapse and their temporal order remain unclear. Here we identify peroxisomal function as a critical regulator of metabolic flexibility during youth and low-energy states. Using Caenorhabditis elegans, we show that fasting robustly induces peroxisomal function in youth, whereas this response is blunted during aging.
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