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Arshay Grant

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Articles

Detection of non‐native species formed during fibrillization of the myocilin olfactomedin domain

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By Hailee F Scelsi, Elijah Dunn, Nebojša Bogdanović, Arshay Grant
| Wiley Online Library Verified
1 INTRODUCTION For globular amyloidogenic proteins, the fibrillization pathway from native protein to end-point fibrils is thought to include intermediate species such as oligomers and protofibrils (Fändrich 2012). The evolution from oligomer to protofibril to fibril results in a heterogeneous mixture of species that can be challenging to characterize in detail (Chiti and Dobson 2017).
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