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Arthur Barakat on Muck Rack

Arthur Barakat

As seen in: BioRxiv
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Articles

A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making

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By Nicolas Clairis, Arthur Barakat, Jules Brochard, Lijing Xin
| BioRxiv
Abstract Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and the anterior insula (aIns) play crucial roles in effort-based decision-making. Here, we investigate the influence of lactate, a key metabolite involved in energy metabolism and signaling, on decisions involving both physical and mental effort, as well as its effects on neural activation.
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A neurometabolic mechanism for effort-based decision-making in the dmPFC/dACC

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By Nicolas Clairis, Arthur Barakat, Jules Brochard, Lijing Xin
| BioRxiv
Abstract Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and the anterior insula (aIns) play crucial roles in effort-based decision-making. Here, we investigate the influence of lactate, a key metabolite indicating energy deficit, on decisions involving both physical and mental effort, as well as its effects on neural activation.
Open in Who Shared Issue with article?

A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making

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By Arthur Barakat, Nicolas Clairis, Jules Brochard, Mathias Pessiglione
| BioRxiv
Abstract Exploring why individuals vary in their willingness to exert effort is pivotal for understanding human motivation. Here, we utilized proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla on the dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and anterior insula (AI) to uncover neurometabolic factors that influence these differences.
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