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As seen in: Frontiers in Immunology
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From hormonal immunomodulation to glioblastoma therapy: the emerging role of Ouabain

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By João Pessoa, Daniel Arruda, Arthur Gomes de, Deyse Cristina Madruga
| Frontiers in Immunology
1 Introduction Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by rapid proliferation, diffuse invasion into surrounding brain tissue, and resistance to conventional therapies (1, 2). Standard treatment typically involves maximal surgical resection followed by radiotherapy and chemotherapy [i.e., temozolomide (TMZ)] (3). However, despite their widespread use, the success rate of treatment remains low due to intrinsic and acquired resistance mechanisms.
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