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Low Soluble Syndecan-1 Precedes Preeclampsia

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By Reproductive Sciences, Andrew D. Althouse, Robin E. Gandley, Arundhathi Jeyabalan
| PLOS
Syndecan-1 (Sdc1; CD138) is a major transmembrane heparan sulfate proteoglycan expressed on the extracellular, luminal surface of epithelial cells and syncytiotrophoblast, thus comprising a major component of the glycocalyx of these cells. The “soluble” (shed) form of Sdc1 has paracrine and autocrine functions and is normally produced in a regulated fashion.
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