Asaul Gonzalez

Abstract There is a strong need for multispecific antibodies that possess favorable clinical properties and can be generated through a simple and efficient process. Here, we repurpose the native IgG Fc–FcγR interaction into a universal, covalent docking site using only a single engineered disulfide bond, providing a simple solution to bypass the complex, bespoke engineering typically required for multispecific antibody design.