Asha Raju

Loading metrics Open Access Peer-reviewed Research Article Citation: Carvalho CA, Abu-Shach UB, Raju A, Vershinin Z, Levy D, Boxem M, et al. (2025) SUMO-mediated regulation of H3K4me3 reader SET-26 controls germline development in C. elegans. PLoS Biol 23(1): e3002980. https://doi.org/10.1371/journal.pbio.3002980 Academic Editor: René F. Ketting, Institute of Molecular Biology, GERMANY Received: March 18, 2024; Accepted: December 11, 2024; Published: January 6, 2025 Copyright: © 2025 Carvalho et al.

Abstract ULP-2 is a conserved SUMO protease required for embryonic development in C. elegans. Here we revealed that ULP-2 controls germline development by regulating the PHD-SET domain protein, SET-26. Specifically, the ulp-2 mutant hermaphrodites exhibit increased sterility and progressive elevation in global protein sumoylation. In the progeny of homozygous animals, meiosis is arrested at the diplotene stage and the cells in the proximal germline acquire a somatic fate.