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Assiatu Crossman on Muck Rack

Assiatu Crossman

As seen in: Nature
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Articles

Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides - Nature Immunology

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By Assiatu Crossman, Yousuke Takahama, Miho Shinzawa, William Hajjar
| Nature Verified
Abstract Thymocytes signaled by T cell antigen receptors to undergo positive selection acquire different functional fates while migrating through the thymus, but how this occurs remains uncertain. We now report that encoding CD8 co-receptors in both Cd4 and Cd8 gene loci modulates major histocompatibility complex (MHC-I) class I T cell antigen receptor signaling duration to generate all potential CD8+ T cell subsets.
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How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion - Nature Immunology

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By Alyssa C Indart, Assiatu Crossman, Xuyu Zhou
| Nature Verified
Abstract Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to differentiate into specialized regulatory T (Treg) or effector T (Teff) CD4+ cells. How these different fates are achieved during development remains poorly understood.
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