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Aswhin Balaji on Muck Rack

Aswhin Balaji

As seen in: BioRxiv
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Articles

Pre-fusion AAA+ remodeling of target-SNARE protein complexes enables synaptic transmission

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By K White, Yousuf A. Khan, Kangqiang Qiu, Aswhin Balaji
| BioRxiv
Abstract Membrane fusion is driven by SNARE complex formation across cellular contexts, including vesicle fusion during synaptic transmission. Multiple proteins organize trans-SNARE complex assembly and priming, leading to fusion. One target membrane SNARE, syntaxin, forms nanodomains at the active zone, and another, SNAP-25, enters non-fusogenic complexes with it.
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