Atishay Mathur on Muck Rack

Atishay Mathur

As seen in: Nature
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Articles

Engineering B cells to express fully customizable antibodies with enhanced Fc functions

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By Chun H. Huang, Atishay Mathur, Xiaoli Huang, Hsu-Yu Chen, Zachary Davis, Karla O’Dell, Elizabeth A. Shuman, Raymond W. Kung, Geoffrey Rogers, Paula M. Cannon, Chan-Hua Chang
| Nature
Abstract Genome editing within the constant region of the immunoglobulin Heavy chain locus (IGH) can reprogram B cells to express heavy-chain-only antibodies (HCAbs) containing custom antigen-recognition domains. HCAb-engineered cells express both surface B cell receptor (BCR) and secreted antibody isoforms and respond to antigen.
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Reprogramming human B cells with custom heavy-chain antibodies - Nature Biomedical Engineering

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By Geoffrey Rogers, Atishay Mathur
| Nature
Abstract The immunoglobulin locus of B cells can be reprogrammed by genome editing to produce custom or non-natural antibodies that are not induced by immunization. However, current strategies for antibody reprogramming require complex expression cassettes and do not allow for customization of the constant region of the antibody.
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Reprogramming human B cells with custom heavy chain antibodies

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By Geoffrey Rogers, Chun Hong Huang, Xiaoli Huang, Atishay Mathur
| biorxiv.org
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