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Atsuji Kodama on Muck Rack

Atsuji Kodama

As seen in: Nature, ACS Publications
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Articles

Polymerization-Induced Functional Switching of Engineered Polyhydroxyalkanoate Synthase Directs Block Copolymerization Click to copy article link Article link copied!

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By Atsuji Kodama, Hiroya Tomita, Kengo Yanagawa
| ACS Publications
Abstract Click to copy section linkSection link copied! Enhancing the physical properties and functionality of polyhydroxyalkanoates (PHA) is essential for expanding their applications, and controlling monomer sequence is central to this goal. Finding the first sequence-regulating PHA synthase, PhaCAR, previously enabled to biosynthesize PHA block copolymers, whereas the molecular mechanism underlying the spontaneous block copolymerization has remained unclear.
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A system of paired polyether epoxide hydrolases enables a mouldable enzyme for consecutive ring cyclization cascades

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By Atsushi Minami, Taro Ozaki, Shusuke Sato, Aoi Sugiyama, Takashi Tadokoro, Tomoyasu Aizawa, Tomo Nomai, Takanori Matsumaru, Junyang Liu, Tao Ye, Susumu Uchiyama, Kowit Hengphasatporn, Yasuteru Shigeta, Tomohide Saio, Katsumi Maenaka, Min Yao, Hiroyuki Kumeta, Hideaki Oikawa, Toyoyuki Ose, Nana Yabuno, Yuki Owada, Kohei Sawada, Ayaka Arai, Takuya Dosen, Atsuji Kodama
| Nature Verified
Abstract Ionophore polyethers, a major class of polyketide-derived natural products, are characterized by molecular skeletons featuring arrays of tetrahydrofuran and tetrahydropyran rings. However, the precise mechanism underlying their biosynthesis, suggested to occur by a sequential epoxide-opening and ether cyclization cascade to generate more than two ether rings, remains elusive.
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