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A Correction on Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression By Shimizu T, Ohkuma R, Homma M, Nakayama S, Sasaki Y, Muto S, Ieguchi K, Watanabe M, Taguchi A, Takayanagi D, Wada Y, Horiike A, Kubota Y, Ariizumi H, Shimokawa M, Hirasawa Y, Ishiguro T, Suzuki R, Iriguchi N, Mura E, Yoshimura K, Tsuji M, Kiuchi Y, Suzuki H and Yamochi T (2025) Front. Immunol. 16:1528594.
1 Introduction The efficacy of immune checkpoint inhibitors (ICIs) has been linked to the gut microbiota. Landmark studies in mice and humans have demonstrated that certain commensal bacteria could enhance antitumor immunity and improve ICI response (1, 2). Conversely, microbiome disruption (e.g., by antibiotics) before or during ICI therapy is associated with significantly worse survival outcomes in studies from our institute and others (3, 4).
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