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Articles by Atul Singhal
Efficacy and Safety of ABBV‐154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo‐Controlled Trial
Supporting Information Filename Description art43266-sup-0001-Disclosureform.pdfPDF document, 582 KB Disclosure Form art43266-sup-0002-Supinfo.pdfPDF document, 232.3 KB Supplementary Table 1. Change from baseline to week 12 (placebo-controlled period) in components of ACR50 score Supplementary Table 2. Concentrations of total ABBV-154, total antibody, and Supplementary Table 3. Safety overview and most common TEAEs for all ABBV- Supplementary Table 4.
Efficacy and Safety of ABBV‐154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo‐Controlled Trial
INTRODUCTION Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by synovitis leading to pain, swelling, stiffness, and progressive disability and destruction of the joints.1 The treatment target for every patient with RA is achieving sustained remission or low disease activity (LDA).2 Many disease-modifying antirheumatic drugs (DMARDs) are available, including conventional synthetic DMARDs (csDMARDs), biologic DMARDs (bDMARDs), and targeted synthetic DMARDs...
Childhood obesity and its consequences across the lifecourse: a call for abstracts
We are pleased to invite submissions of abstracts for oral presentation at The Lancet Summit on childhood obesity: consequences across the lifecourse.
How much loss to follow-up is acceptable in long-term randomised trials and prospective studies?
There is increasing evidence that health and development in adult life is influenced or “programmed” by factors, including nutrition, operating during foetal life and infancy. Early nutrition in a variety of animal species, including primates, has been demonstrated to influence later outcomes, including the likelihood of cardiovascular disease, learning and behaviour problems and longevity (see supplementary data).
How much loss to follow-up is acceptable in long-term randomised trials and prospective studies?
There is increasing evidence that health and development in adult life is influenced or “programmed” by factors, including nutrition, operating during foetal life and infancy. Early nutrition in a variety of animal species, including primates, has been demonstrated to influence later outcomes, including the likelihood of cardiovascular disease, learning and behaviour problems and longevity (see supplementary data).
Weight centile crossing in infancy: correlations between successive months show evidence of growth feedback and an infant-child growth transition
↵ 1 Supported by Medical Research Council grant MR/M012069/1 and the Great Ormond Street Hospital Children's Charity and by the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children, NHS Foundation Trust, and University College London. This is an open access article distributed under the CC-BY license ( http://creativecommons.org/licenses/by/3.0/ ).
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