Audrys G. Pauza

Handling Editors: Kim Barrett & Andrew Holmes Gold, O.M.S., Pauza, A.G., Felippe, I.S.A., Shen, X. and Paton, J.F.R. (2026), Amino acid modulation of the carotid body selectively modulates peripheral chemoreceptor respiratory reflex. J Physiol. https://doi.org/10.1113/JP289334 Data availability statement All individual data points supporting the findings of this study are presented within the figures of the manuscript.

Introduction Affecting nearly 12% of the world's population, hypertension can be considered a global pandemic (Mills et al., 2020). High blood pressure is the single most important modifiable risk factor for cardiovascular disease, which is the leading cause of morbidity and mortality globally (Blakely et al., 2019; Forouzanfar et al., 2017; GBD 2019 Risk Factors Collaborators, 2020).