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Obesity and Early‐Stage Breast Cancer: A Comprehensive Analysis of Tumor Biology, Staging Accuracy, and Long‐Term Outcomes
1 Introduction Breast cancer remains the leading cause of cancer-related mortality among women worldwide, with approximately 2.3 million new diagnoses and 685,000 deaths reported in 2020 [1-4]. In Italy alone, an estimated 55,000 new cases are reported annually [5]. Established risk factors include advanced age, family history, and hereditary genetic mutations [5]. However, obesity has emerged as a major modifiable risk factor influencing both the incidence and progression of breast cancer.
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