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Auryane Laure Cabald on Muck Rack

Auryane Laure Cabald

As seen in: Nature
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Articles

GSK-3 regulates CD4-CD8 cooperation for super-armed CD8+ cytolytic T cells in immunotherapy against tumors

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By Bastien Moes, Janna Krueger, Chen Liu, Nikhil Ponnoor Anto, Mikhael Attias, Alexandra Kazanova, Yunfeng Gao, Andres Oroya, Lan Huong Nguyen, Thái Tú, Christopher E. Rudd, Atena Nemati, Linda Castoun-Puckett, Auryane Laure Cabald
| Nature Verified
Abstract Although the efficacy of immune checkpoint blockade (ICB) depends on coordinated activity across progenitor and terminal effector CD4⁺ and CD8⁺ T-cell compartments, the cell-intrinsic pathways that enable this cooperation remain incompletely defined. Here, we identify glycogen synthase kinase-3 (GSK-3) as a central regulator of TCF-1⁺ progenitor and memory CD8⁺ T-cell differentiation, where reduced GSK-3 expression enhances antiviral and anti-tumor immunity.
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