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Euploidy rates in donor egg cycles significantly differ between fertility centers
Genetic screening of thousands of human embryos in the past two decades has clearly established that the incidence of numeric chromosome abnormalities is very high following ovarian stimulation and IVF, overall exceeding 50% of biopsied embryos (Munné et al., 1995; Magli et al., 2001; Ata et al., 2012). A majority of aneuploidies are meiotic in origin and known to be maternal age related (Hassold et al., 1980).
Phase III randomized controlled trial comparing the efficacy, safety and tolerability of oral dydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization | Human Reproduction | Oxford Academic
Luteal phase support, in conjunction with gonadotropin-releasing hormone analogs, is routinely performed during in vitro fertilization (IVF) procedures to overcome luteal phase progesterone deficiency induced by ovarian stimulation (Practice Committee of the American Society for Reproductive Medicine, 2008; Palomba et al., 2015).
Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos
The role of mitochondrial function and proper energy production in the developing human embryo is thought to be critical to successful implantation and delivery (Van Blerkom et al., 1995).
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