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A DIY guide for image-based spatial transcriptomic: TLS as a case example

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By Thomas Defard, Charles Fouillade, Florian Mueller, Auxence DESRENTES
| biorxiv.org
Abstract Spatial RNA profiling methods provide insight to the cellular heterogeneity and spatial architecture of complex, multi-cellular systems. Combining molecular and spatial information provides important clues to study tissue architecture in development and disease. Here, we present a comprehensive do-it-yourself guide to perform such experiments at reduced costs leveraging open-source approaches.
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