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Avalon Patton

As seen in: Cell Reports Medicine
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Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy

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By Ruben Rodriguez, Anne E. Hergarden, SHYAM KRISHNAN, Davina Lam, Teresa Tang Verified, Craig Lee, Asmita Pant Verified, Daniel A. Erlanson, Derek B. Bone, Damian Bialonczyk, Jian Luo, Manu Chakravarthy, Marikris Morales, Ted Tracy, Avalon Patton, Johan Enquist, Ray Fucini, Stig K. Hansen
| Cell Reports Medicine Verified
Keywords obesity incretins biased signaling receptor internalization glycemic control food intake regulation intracerebroventricular injections brain Introduction In the United States, the prevalence of obesity among adults has increased from 13% in 1960 to over 40% by 2017, paralleling a significant rise in the prevalence of type 2 diabetes (T2D).1,2 In response, the biopharmaceutical and medical communities have dedicated significant efforts to developing therapies that simultaneously lower...
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