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Synthesis of skeletally diverse β-lactam haptens for the in vitro diagnosis of IgE-mediated drug allergy
Synthesis of skeletally diverse β-lactam haptens for the in vitro diagnosis of IgE-mediated drug allergy† Edurne Peña-Mendizabal,a Bruce K. Hua,bc Ethel Ibañez-Echevarria,d Dolores Hernández-Fernández de Rojas,e Ángel Maquieira,afg Stuart L. Schreiberbc and Sergi Morais *afg Abstract We present the first synthesis of β-lactam-derived haptens, leveraging the principles of diversity-oriented synthesis to discover compounds for drug allergy in vitro testing.
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