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Avril Kaye Coley on Muck Rack

Avril Kaye Coley

As seen in: BioRxiv
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Articles

Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma

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By Avril Kaye Coley, Bidish K. Patel, Amaya Pankaj, Cole Nawrocki
| BioRxiv
Abstract Purpose: Hepatocellular carcinoma (HCC) is a lethal malignancy driven by complex interactions between cancer cells, immune cells, and additional stromal cells in the tumor microenvironment (TME). The LINE1 retrotransposon is a ubiquitous repeat RNA whose de-repression leads to significant cancer cell-intrinsic and TME changes that promote aggressive tumor characteristics.
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Dysregulated Repeat Element Viral-like Immune Response in Hepatocellular Carcinoma

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By Chenyue Lu, Amaya Pankaj, Matthew J. Emmett, Avril Kaye Coley
| BioRxiv
Abstract Purpose: Dysregulation of viral-like repeat RNAs are a common feature across many malignancies that are linked with immunological response, but the characterization of these in hepatocellular carcinoma (HCC) is understudied.
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