Ayan Kumar Barui

Intra-Mitochondrial Self-Assembly to Overcome the Intracellular Enzymatic Degradation of L-peptides. The design of peptide-based therapeutics is generally based on the replacement of L-amino acids with D-isomers to obtain improved therapeutic efficiency. However, D-isomers are expensive and frequently induce undesirable immune responses. In the present work, we demonstrate that an intra-mitochondrially self-assembling amphiphilic peptide exhibits analogous activity for both D and L isomeric forms.

Angiogenesis is a vital process which deals with the generation of new blood vessels from pre-existing vasculature and well-known to regulate various physiological as well as pathophysiolgical processes. We demonstrated that zinc oxide nanoflowers (ZONF) exhibited pro-angiogenic property to endothelial cells through the production of intracellular reactive oxygen species (ROS), especially H2O2 (hydrogen peroxide).

In the present study, we report the delivery of anti-cancer drug curcumin to cancer cells using mesoporous silica materials. A series of mesoporous silica material based drug delivery systems (S2, S4 and S6) were first designed and developed through the amine functionalization of KIT-6, MSU-2 and MCM-41 followed by the loading of curcumin.