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Aybaran O Kebabci

As seen in: BioRxiv
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Articles

Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

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By Alexander Winkel, Kristian Franze, Adam M Rochussen, Aybaran O Kebabci
| BioRxiv
Abstract Cytotoxic T lymphocytes (CTLs) are cells of the adaptive immune system that are able to recognise and kill cancerous or virally infected target cells. The biochemical basis of CTL-mediated killing has been examined in great detail. Recent work has underscored the importance of physical forces in T cell function too, but how CTLs sense and exert force during migration and killing is not fully understood.
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