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Ayinalem Alemu on Muck Rack

Ayinalem Alemu

As seen in: Nature, Wiley Online Library, PLOS ONE, BMJ Open, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles

Whole genome sequencing-based detection of extensively drug-resistant tuberculosis from Ethiopia - Communications Medicine

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By Getu Diriba, Hilina Mollalign, Abyot Meaza, Melak Getu, Betselot Zerihun, Ayinalem Alemu, Biniyam Dagne, Yeshiwork Abebaw, Chala Bashea, Getachew Seid, Muluwork Getahun, Feyissa Challa, Tsegaye Getachew, Negga Asamene Abera
| Nature Verified
Abstract Rapid and accurate detection of extensively drug-resistant tuberculosis is crucial for effective intervention. Next-generation sequencing technologies have been recommended to rapidly and accurately detect resistance to second-line anti-TB drugs. We deployed whole-genome sequencing to detect mutations associated with drug resistance in pre-extensively drug-resistant tuberculosis and extensively drug-resistant tuberculosis strains in Ethiopia.
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Active tuberculosis in household contacts of bacteriologically confirmed pulmonary tuberculosis patients: A multicenter study finding the ‘Missed One’ in Central Ethiopia

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By Getachew Seid, Addis Ababa, Ayinalem Alemu, Getu Diriba
| PLOS ONE
Citation: Seid G, Alemu A, Diriba G, Hailu M, Wondimu A, Tadesse M, et al. (2025) Active tuberculosis in household contacts of bacteriologically confirmed pulmonary tuberculosis patients: A multicenter study finding the ‘Missed One’ in Central Ethiopia. PLoS ONE 20(2): e0316903.
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A smooth tubercle bacillus from Ethiopia phylogenetically close to the Mycobacterium tuberculosis complex - Nature Communications

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By Bazezew Yenew, Arash Ghodousi, Andrea Maurizio Cabibbe, Ayinalem Alemu, Hilina Mollalign, Xavier Didelot, Muluwork Getahun, Philip Supply, Shewki Moga, Binyam Dagne, Waganeh Sinshaw, Abyot Meaza, Betselot Zerihun, Melak Getu
| Nature Verified
Abstract The Mycobacterium tuberculosis complex (MTBC) includes several human- and animal-adapted pathogens. It is thought to have originated in East Africa from a recombinogenic Mycobacterium canettii-like ancestral pool. Here, we describe the discovery of a clinical tuberculosis strain isolated in Ethiopia that shares archetypal phenotypic and genomic features of M. canettii strains, but represents a phylogenetic branch much closer to the MTBC clade than to the M. canettii strains.
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