Ayni Sharif

ASR test Request a detailed protocol The ASR test was conducted based on a recent study (Pantoni et al., 2020). In our study, a sound-proof box was purchased, in which a trumpet, a high-speed camera (200 frames per second, Plexon), and a box made from acrylic plate (10 cm [L] × 5 cm [W] × 25 cm [H]) were prepared. Mice exposed to sound at 105 dB measured by a decibel meter exhibited obvious startle response while 75 dB evoked no response.

eLife Assessment This study is important, and the findings add substantially to the evidence base regarding CCR5 antagonist drugs for neuroprotection and stroke management. The authors adhered to the expected systematic review and meta-analysis standards, and the presented evidence is convincing.

Abstract C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use. With a panel of patients with lived experiences of stroke, we performed a systematic review of animal models of stroke that administered a CCR5 antagonist and assessed infarct size or behavioural outcomes. MEDLINE, Web of Science, and Embase were searched.