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Ayrun Nessa on Muck Rack

Ayrun Nessa

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Articles

Long-read sequencing reveals pre-meiotic gene conversion in sperm

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By Regev Schweiger, Sangjin Lee, Chenxi Zhou, Tsun-Po Yang, Stacy Y. Li, Rashesh Sanghvi, Matthew Neville, Katie Smith, Kirsty Roberts, Kerrin S. Small, Peter Campbell Verified, Kristian Almstrup, Peter H. Sudmant, Raheleh Rahbari, Richard Durbin, Ayrun Nessa, Sam Wadge
| Nature Verified
Abstract Meiotic recombination is a fundamental process that generates genetic diversity by creating new combinations of existing alleles1. Whereas crossovers in humans are well characterized2, the more frequent non-crossovers that lead to gene conversion remain challenging to study. Here we show that single high-fidelity long sequencing reads from sperm can capture both crossovers and non-crossovers, which enables effectively arbitrary sample sizes for analysis from a single male.
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