Ayse Mine Yilmaz

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description cbdv70692-sup-0001-SuppMat.docx1.4 MB Supporting File 1: cbdv70692-sup-0001-SuppMat.docx References 1, , , et al., “Transcriptional Landscape of the Human Cell Cycle,” PNAS 114 (2017): 3473–3478, https://doi.org/10.1073/pnas.1617636114.

1 Introduction Cancer continues to be at the top of the list of diseases that seriously threaten human health and quality of life with its high incidence and mortality rate. According to data based on the latest GLOBOCAN estimates produced by the International Agency for Research on Cancer (IARC) and published in the Global Cancer Observatory as Cancer Today, 9,743,832 of the 19,976,499 cancer cases observed in 2022 resulted in death (WHO 2022).