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Aziza Bachir on Muck Rack

Aziza Bachir

As seen in: Frontiers in Immunology
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Articles

Major histocompatibility complex class II deficiency in Morocco: a 26-year retrospective cohort study

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By Aziza Bachir, Hassan II, Cadi Ayyad
| Frontiers in Immunology
Abstract Major histocompatibility complex class II (MHC-II) deficiency is a rare autosomal recessive combined immunodeficiency caused by defects in transcriptional regulators controlling HLA class II expression. The disorder is more prevalent in North Africa due to high rates of consanguinity and founder effects. Updated national data remain limited (in Morocco, up-to-date national data on this deficit remain limited).
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Case Report: A novel CIITA mutation causing MHC class II deficiency: first reported case in Morocco

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By Aziza Bachir, Hassan II, Drissi Bourhanbour, Ahmed Aziz
| Frontiers in Immunology
Introduction Major histocompatibility complex class II (MHC II) deficiency, also known as bare lymphocyte syndrome type II, is an autosomal recessive combined immunodeficiency caused by mutations in one of four key transcriptional regulators of MHC-II gene expression: CIITA (group A), RFXANK (group B), RFX5 (group C) or RFXAP (group D) (1–3).
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