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Azmal Ali Syed on Muck Rack

Azmal Ali Syed

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Functional characterization of snoRNA-derived RNA (sdRNA) expression in healthy hematopoiesis and acute myeloid leukemia

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By Christian Rohde, Cornelius Pauli, Fengbiao Zhou, Daniel Heid, Viral Shah, Niklas Wahl, Adrija Ray, Simon Renders, Laura Werner, Claudia D. Baldus, Martin Bornhauser, Christoph Röllig, Hubert Serve, Tim Sauer, Jeroen Krijgsveld, Carsten Müller-Tidow, Maximilian Felix Blank, Rafael Zinz, Azmal Ali Syed, Sandra Förmer, Carl Ahrens
| Nature Verified
Abstract SnoRNAs are highly expressed in AML and have implications in leukemogenesis and leukemic maintenance. SnoRNAs can be further processed into snoRNA-derived RNAs (sdRNAs). The role of sdRNAs in AML and healthy hematopoiesis remains largely elusive. We characterized sdRNA and snoRNA levels in hematopoietic stem and progenitor cells (HSPCs), healthy WBCs, and 159 intensively treated AML patient samples at initial diagnosis.
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