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RNA binding regulation is a new dimension in the type I IFN response

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By Louisa Iselin, Yana Demyanenko, Natasha Palmalux, Azman Embarc Buh
| biorxiv.org
Abstract The type I interferon (IFN-I) response shapes the intracellular environment to supress virus infection. Historically, this remodelling has been linked to the transcriptional induction of interferon stimulated genes (ISGs). However, IFN-I-driven post-translational regulation of proteins already present in the cell remains relatively unexplored. Here, we profiled the activity of cellular RNA-binding proteins (RBPs), which are key players in antiviral immunity.
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