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Original Paper This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/uog.26306. ABSTRACT Objective Preeclampsia (PE) is a pregnancy complication associated with premature cardiovascular disease morbidity and mortality.
What are the novel findings of this work? Epidural analgesia (EDA) is associated with a higher risk of emergency delivery for presumed fetal compromise compared with no analgesia and alternative forms of analgesia. Relative risks of fetal compromise after EDA vs no analgesia were modestly but consistently modified by birth-weight centile, supporting the theory that reduced placental reserves exacerbate the adverse effect on the fetus of maternal hemodynamic changes induced by EDA.
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