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Pancreatic Adenocarcinoma: An Evolving Yet Unimpressive Treatment Landscape
Improvement in treatment outcomes for pancreatic adenocarcinoma (PA) has been substantial since 1980s, owing in large part to improved operative mortality rates of < 3%1 and to the advent of effective chemotherapy and radiotherapy approaches.2-4 As Jiang et al5 illustrate in their accompanying review, the effectiveness of adjuvant chemotherapy has significantly improved to an impressive median overall survival (mOS) of 54.4 months with modified (m)folinic acid, fluorouracil, irinotecan, and...
Pancreatic Adenocarcinoma: An Evolving Yet Unimpressive Treatment Landscape
Improvement in treatment outcomes for pancreatic adenocarcinoma (PA) has been substantial since 1980s, owing in large part to improved operative mortality rates of < 3%1 and to the advent of effective chemotherapy and radiotherapy approaches.2-4 As Jiang et al5 illustrate in their accompanying review, the effectiveness of adjuvant chemotherapy has significantly improved to an impressive median overall survival (mOS) of 54.4 months with modified (m)folinic acid, fluorouracil, irinotecan, and...
Immune checkpoint inhibitors in luminal gastrointestinal malignancies: going beyond MSI-H/dMMR, TMB and PD-L1 | Immunotherapy
DS Lefler has no conflicts to disclose. AE Snook is a consultant for Targeted Diagnostics and Therapeutics Inc., which provided research funding that, in part, supported this work and has a license to commercialize inventions related to this work. AE Snook was supported by the Defense Congressionally Directed Medical Research Programs (#W81XWH-19-1-0263), West Pharmaceutical Services Inc., the Courtney Ann Diacont Memorial Foundation, and Lorraine and David Swoyer.
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