Bagrat Grigoryan

Interstitial cystitis/bladder pain syndrome (IC/BPS) remains a highly debilitating condition with elusive etiology and largely symptomatic treatments. Our systematic review aimed to clarify whether ferroptosis, a form of iron-dependent cell death, could serve as a mechanistic bridge linking chronic inflammation to progressive bladder injury.

Abstract Spatial patterns of gene expression in living organisms orchestrate cell decisions in development, homeostasis, and disease. However, most methods for reconstructing gene patterning in 3D cell culture and artificial tissues are restricted by patterning depth and scale. We introduce a depth- and scale-flexible method to direct volumetric gene expression patterning in 3D artificial tissues, which we call “heat exchangers for actuation of transcription” (HEAT).

Information Published In Science Volume 364 | Issue 6439 3 May 2019 Copyright Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an article distributed under the terms of the Science Journals Default License. Submission history Received: 6 November 2018 Accepted: 9 April 2019 Published in print: 3 May 2019 Permissions Request permissions for this article.