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Bahazd Baradaran on Muck Rack

Bahazd Baradaran

As seen in: Nature
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Articles

Temozolomide alters the expression pattern of immune mediators in monocyte-derived dendritic cells

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By Javad Masoumi, Bahareh Najaflou, Masoumeh Firouzamandi, Farid Ghorbaninezahd, Yaser Jafari-khataylou, Mohadeseh Sadat Hosseini, Bahazd Baradaran
| Nature Verified
Abstract Monocyte-derived dendritic cells (moDCs) are widely used in cancer immunotherapy due to their accessibility and their ability to initiate potent T cell responses. However, the immunosuppressive tumor microenvironment often compromises the therapeutic efficacy of these treatments. Temozolomide (TMZ), an alkylating chemotherapeutic agent widely used in the treatment of glioblastoma, has been proposed to exert additional immunomodulatory effects beyond its cytotoxic role.
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