Tailoring the positive and negative solvatochromism for chalcone analogues to detect heterozygous protein co-aggregation† Bai Yulong,abc Wan Wang,a Huang Yanan,cd Wu Jichun,cd Liu Lihua,cd Jing Biao,ae Chen Junlin,cd Zhang Xin *cd and Liu Yu *a Abstract It is rare for one fluorophore scaffold to harbor both positive and negative solvatochromism. Herein, we tailor chalcone analogues to achieve both positive- and negative-polarity sensitivity of fluorescence intensity.
