Bálint Zoltán Németh

Abstract Recently, fungal infections originating from the probiotic Saccharomyces ‘boulardii’ yeast are increasingly reported. Here, we aimed to reveal the background of and to diminish the virulence of this yeast, mitigating infection risks in vulnerable patient groups. Product and human isolates of S. ‘boulardii’ were subjected to in-host selection and their subclone lineages were compared phenotypically to identify target phenotypes and associated genes.

Abstract Leavening dough is one of the most widespread applications of fermentative yeast and the most common practice for the general public to come into contact with microbial cultures. Saccharomyces cerevisiae is the typical species used for dough making, but the evolutionary origin of strains isolated from dough is mixed.

1 Introduction Eglin C is a 70-amino-acid reversible protease inhibitor originally isolated from Hirudo medicinalis [1, 2]. According to the standard-mechanism model of reversible protease inhibitor proteins, the reactive loop of the inhibitor binds into the substrate-binding groove of the target protease [3].