Baltazar Zavala

To the Editor, We thank the correspondents for their thoughtful appraisal.

CONFLICT OF INTEREST STATEMENT I.N. is on the speakers' bureau of SK Life Science. The remaining authors have no competing interests to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. DATA AVAILABILITY STATEMENT Data cannot be made publicly available, as they contain sensitive personal information.