Banglian Hu

Abstract Background: Shared pathophysiological mechanisms exist between epilepsy and its associated comorbidities, with neuroinflammation playing a key role. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) is a soluble epoxide hydrolase (sEH) inhibitor that exhibits potent, broad-spectrum anti-inflammatory effects by preventing the hydrolysis of epoxyeicosatrienoic acids (EETs).

Keywords CSF1R CSF1R-RD leukoencephalopathy microglia microglia replacement Introduction The colony-stimulating factor 1 receptor (CSF1R) is a tyrosine kinase receptor predominantly expressed on microglia within the central nervous system (CNS). Autosomal dominant mutations in CSF1R cause a progressive leukodystrophy known as adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP),1,2,3,4 characterized by dementia with motor impairments and neuropsychiatric deficits.

Sporopollenin exine capsules modulate the function of microglial cells† Immune cells are the housekeepers of the human body. They protect the body from pathogens, cellular damage, and foreign matter. Proper activation of immune cells is of great significance to diseases such as infection, inflammation, and neurodegeneration. However, excessive activation of cells can be detrimental. An ideal biomaterial could enhance the cellular immune function without proinflammation.