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Banglun Pan on Muck Rack

Banglun Pan

As seen in: Nature, Science Magazine
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Articles

Disruption of RBPJ in liver cancer-infiltrating T cells enhances antitumor immunity through remodeling epigenetic landscape

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By Banglun Pan, Jinqiao Wu, Shuyan Zhou, Zengbin Wang, Dongjie Ye, Zhu Zhang, Yuxin Yao, Hao Wu, Xinyu Zhang, Haoyi Yang, Nanhong Tang
| Nature Verified
Abstract Though inhibiting the RBPJ transcription complex reduces PD-L1 expression and alleviates T cell dysfunction in hepatocellular carcinoma (HCC), the tumor immunomodulatory function of RBPJ in T cells is unclear. This study used patient-derived xenograft models to illustrate the role of RBPJ disruption in clinical outcomes and sensitivity to immunotherapy. Immunoprecipitation was performed to identify whether HUWE1 is the E3 ubiquitin ligase for RBPJ.
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SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape

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By Simon Mitchell, Mateusz Szczerba, Zengbin Wang, Banglun Pan
| Science Magazine Verified
LATEST NEWS SUMO switches off immunosurveillance in liver cancer Interleukin-33 (IL-33) is a dual function protein. As an extracellular cytokine, it is associated with the progression of liver cancer. However, Wang et al. found that as an intracellular factor, IL-33 is tumor suppressive, a function that is blocked by posttranslational modification in liver cancer cells.
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