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Bangwei Mao

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Articles

Discovery and engineering of avian R2 retrotransposons for all-RNA-mediated targeted DNA integration in human cells

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By Yangcan Chen, Yanping Hu, Na Tang, Chenxin Wang, Yuze Wang, Hanyu Bai, Xinge Wang, Qicheng Chen, Jiahui Xiao, Yu Zou, Peng Wang, Rui Niu, Jin Zhang, YuLong Zhao, CHEN LIANG, Yunlong Wang, Yiyun Li, Junjie Wang, Ng Shyh-Chang, Tuo Wei, Haoyi Wang, Qi Zhou, Wei Li, Shengqiu Luo, Bangwei Mao, Changxian Peng
| Nature Verified
Abstract To discover unknown retrotransposons for genomic integration in human cells, we searched 1,139 avian genomes, identified 159 avian R2 retrotransposons and characterized conserved/nonconserved sequence features in their proteins and untranslated region elements. Engineered variants of these retrotransposons achieved up to 60% site-specific gene integration across human primary cells. This work expands the avian R2 resource and provides additional tools for all-RNA-mediated genome editing.
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