Banu Çelikel Acar

Abstract Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) is a common childhood autoinflammatory disease. This study investigated the influence of early-life factors on attack frequency and treatment resistance in children with PFAPA. Eighty-one children with PFAPA (diagnosed April 2021–2024) were retrospectively evaluated and divided into persistent and non-persistent (self-limiting) groups.

To the Editor: Ubiquitylation, a posttranslational modification, is one of the key mechanisms regulating cellular homeostasis in the innate immune system. OTULIN is a deubiquitinase that prevents the accumulation of linear ubiquitin chains in the cell. OTULIN deficiency causes OTULIN-related autoinflammatory syndrome (ORAS), also known as otulipenia, an autosomal recessive disease characterized by uncontrolled inflammation.

ORIGINAL PAPER Gizem Ozcan, orcid.org/0000-0001-9063-4063 Department of Pediatric Pulmonology, Ankara University, Faculty of Medicine, Ankara, Turkey Search for more papers by this author Semsa Cayci, Department of Pediatric Nephrology, Ankara City Hospital, Ankara, Turkey Search for more papers by this author Banu Celikel Acar, Department of Pediatric Rheumatology, Ankara City Hospital, Ankara, Turkey Search for more papers by this author Ozge Basaran, Department of Pediatric Rheumatology,...