Bar Glickstein

Introduction Click to copy section linkSection link copied! Diseases, injuries, and traumatic events often result in tissue damage and degeneration, thereby necessitating therapeutic strategies aimed at repair, replacement, or regeneration. (1) Tissue engineering addresses this need by seeking to restore, maintain, or enhance compromised tissue function, either through the development of biological substitutes or by reconstructing damaged tissues, using natural and synthetic materials.

Anat Globerson Levin Immunology and Advanced CAR-T Cell Therapy Laboratory, Research & Development Department, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, 6423906 Israel Dotan Center for Advanced Therapies, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, 6423906 Israel Search for more papers by this author

1 Introduction The advent of immune checkpoint inhibitors has emerged as a promising immunotherapy strategy for cancer treatment, successfully generating an immune response against cancer cells.[1-3] A primary inhibitory mechanism is the PD-1/PD-L1 pathway.[4] PD-1, a checkpoint protein, present on the surface of T cells, inhibits T cell activation and proliferation when engaged by its ligand, PD-L1, found on normal and tumor cells.[5] This interaction is crucial for maintaining immune...