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Bar Sotil

As seen in: BioRxiv
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Articles

An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans

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By Gábor Hajdu, Milán Somogyvári, Saba Khatatneh, Bar Sotil
| BioRxiv
Abstract Proteostasis maintenance and lipid metabolism are critical for survival and promote longevity, however, their coordination is largely unclear. Here we show that the heat shock factor HSF-1 and the proteostasis state regulates lipolysis in C. elegans. We find that in response to starvation, the sirtuin 1 ortholog SIR-2.1 activates lipolysis by upregulation of the adipose triglyceride lipase ATGL-1.
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