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BARACK-D Investigators

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Articles

Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial - Nature Medicine

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By Richard McManus, Clare Taylor, Nicholas Jones, Jane Wolstenholme, Sungwook Kim, Joseph Sang-II Kwon, Sam Mort, BARACK-D Investigators
| Nature Verified
Abstract Chronic kidney disease (CKD) is associated with a substantial risk of progression to end-stage renal disease and vascular events. The nonsteroidal mineralocorticoid receptor antagonist (MRA), finerenone, offers cardiorenal protection for people with CKD and diabetes, but there is uncertainty if the steroidal MRA, spironolactone, provides the same protection.
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