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Barak Rotblat on Muck Rack

Barak Rotblat

As seen in: Nature, Wiley Online Library, MDPI
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Articles

Pharmacological activation of SIRT6 suppresses progression of head and neck and esophageal squamous cell carcinoma by modulation of cellular metabolism and protein translation | Cell Death & Disease

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By Barak Rotblat, Dexin Kong, Debra Toiber
| Nature Verified
Abstract Sirtuin 6 (SIRT6), a NAD+-dependent histone deacetylase, has been shown to function as a tumor suppressor in several cancer types, including squamous cell carcinoma of the head and neck and the esophagus (HNSCC and ESCC). However, the potential of therapies involving the activation of SIRT6 in HNSCC and ESCC remains unexplored. In this work, we investigated the therapeutic potential and mechanisms of action of the allosteric SIRT6 activator MDL-800 in HNSCC and ESCC models.
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Brillouin gain microscopy - Nature Photonics

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By Roni Shaashoua, Barak Rotblat, Anat Ben-Zvi
| Nature Verified
Abstract Optical imaging techniques with mechanical contrast, including passive microrheology, optical coherence elastography and Brillouin microscopy, are critical for material and biological discovery owing to their less perturbative nature compared with traditional mechanical imaging methods.
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mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism - Nature Communications

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By Khawla Alasad, Marteinn Thor Snaebjornsson, Melanie Planque, Cornelius M. Funk, Daniel Picard, Andres Vargas-Toscano, Ulf D. Kahlert, Andreas Reichert, Sarah-Maria Fendt, Almut Schulze, Barak Rotblat, Alisa Kahler
| Nature Verified
Abstract Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose starvation. How mTORC1 controls cell viability during glucose starvation is not well understood. Here we show that the mTORC1 effectors eukaryotic initiation factor 4E binding proteins 1/2 (4EBP1/2) confer protection to mammalian cells and budding yeast under glucose starvation.
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