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Baran Dingiloglu on Muck Rack

Baran Dingiloglu

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A BAG-1-inhibitory peptide, GO-Pep, suppresses c-Raf activity in cancer - Communications Biology

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By Özge Tatli, Miray Turk, Baran Dingiloglu, Ezgi Basturk
| Nature Verified
Abstract BAG-1 interacts with multiple partners, particularly with c-Raf, and promotes cancer cell survival. Hence, modulating the BAG-1-associated interactions with novel inhibitors could provide benefit for cancer therapy. Using HDX-MS, we first demonstrate the higher-order structure of BAG-1S and identify a potential “druggable” site on its BAG domain.
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