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NSCLC brain metastases exhibit reduced HLA-I antigen presentation machinery and immune evasion independent of IFNγ signaling defects
Competing interests N.V. served as a consultant, advisor, or speaker for AstraZeneca, Takeda, Bristol-Myers Squibb, Roche, Merck, Boehringer-Ingelheim, Pfizer, and Novocure. A.C. served as a consultant for Bristol-Myers Squib.
IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer - Molecular Cancer Original
Formalin-fixed paraffin-embedded (FFPE) samples from four previously reported retrospective collections of primary NSCLCs represented in tissue microarrays (TMAs) were analyzed [9]. The first collection includes samples from 273 patients with NSCLC collected at Sotiria General Hospital and Patras University General Hospital (Greece) between 1991 and 2001 (cohort #1).
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