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Intraperitoneal transplant of Hepatocytes co-Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute Liver failure in Pediatric patients (HELP)-An open-label, single-arm Simon’s two stage phase 1 study protoc
PLOS ONE, Jul 2023 Background Pediatric acute liver failure (PALF) carries a high mortality without liver transplantation (LT) in children. Liver transplantation, though lifesaving, is limited by timely donor organ availability, the risks of major surgery and complications of life-long immunosuppression. Hepatocyte transplantation (HT) improves synthetic and detoxification functions in small animal models.
Intraperitoneal transplant of Hepatocytes co-Encapsulated with mesenchymal stromal cells in modified alginate microbeads for the treatment of acute Liver failure in Pediatric patients (HELP)-An open-label, single-arm Simon’s two stage phase 1 study protoc
Loading metrics Open Access Study Protocol Abstract Background Pediatric acute liver failure (PALF) carries a high mortality without liver transplantation (LT) in children. Liver transplantation, though lifesaving, is limited by timely donor organ availability, the risks of major surgery and complications of life-long immunosuppression. Hepatocyte transplantation (HT) improves synthetic and detoxification functions in small animal models.
L8 Acute liver failure and hepatitis associated aplastic anaemia: a 17-year single centre experience
L8 Acute liver failure and hepatitis associated aplastic anaemia: a 17-year single centre experience Vaia Zouzo1, Kavitha Jayaprakash2, Barath Jagadisan2, Palaniswamy Karthikeyan2, Marumbo Mtegha2, Sanjay Rajwal2 1Leeds Children’s Hospital Leeds General Infirmary 2Paediatric Liver Unit, Leeds Children’s Hospital, Leeds General Infirmary Abstract Introduction/Background Hepatitis-associated aplastic anaemia (HAAA) and Acute Liver Failure associated aplastic anaemia (ALF-AA) is a...
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